解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The vascular actions of insulin are complex, because it can stimulate both nitric oxide-mediated dilatation and endothelin (ET)-1-mediated constriction. We examined vasoreactivity to insulin in isolated feed arteries of the gastrocnemius (GFA) and soleus muscles (SFA) of 32-week-old Long-Evans Tokushima Otsuka (LETO) ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2013.074047
更新日期:2014-01-01 00:00:00
abstract::Neuropeptides and regulatory peptide hormones control many developmental, physiological and behavioural processes in animals, including humans. The nonapeptides oxytocin and arginine vasopressin are produced and released by the pituitary gland and have actions on many organs and tissues. Receptive cells possess partic...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2013.072561
更新日期:2014-01-01 00:00:00
abstract::Aortic bodies are arterial chemoreceptors presumed to monitor blood O2 content by unknown mechanisms, in contrast to their well-studied carotid body counterparts, which monitor PO2 and /pH. We recently showed that rat aortic body chemoreceptors (type I cells), located at the left vagus-recurrent laryngeal nerve bifurc...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2013.075408
更新日期:2014-01-01 00:00:00
abstract::Altered systemic haemodynamics following exercise can compromise cerebral perfusion and result in syncope. As the Wingate anaerobic test often induces presyncope, we hypothesized that a modified Wingate test could form the basis of a novel model for the study of postexercise syncope and a test bed for potential counte...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2013.075333
更新日期:2014-01-01 00:00:00
abstract::The hypothalamus regulates the key hormonal signalling events essential for reproduction and fertility in mammals. The gonadotrophin-releasing hormone (GnRH) neurons are the principal neurons of the complex neuronal network that co-ordinates multiple internal homeostatic and external factors necessary for fertility. K...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2013.071944
更新日期:2013-11-01 00:00:00
abstract::Sympathetic baroreflex sensitivity is increased during selective activation of the skeletal muscle metaboreflex with postexercise ischaemia (PEI) in young adults. However, to date, there are no data demonstrating this neural interaction between the arterial baroreflex and the muscle metaboreflex in healthy older adult...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2013.073189
更新日期:2013-10-01 00:00:00
abstract::Early life and preconception environmental stimuli can affect adult health-related phenotypes. Exercise training is an environmental stimulus affecting many systems throughout the body and appears to alter offspring phenotypes. The aim of this study was to examine the influence of parental exercise training, or 'exerc...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.070300
更新日期:2013-10-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? A transcranial magnetic stimulation (TMS)-induced twitch applied on isolated single breaths over the motor cortex somatotopic representation of the tongue briefly recruits submental muscles and improves airflow dynamics of flow-limited respiratory cycles without ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2013.073072
更新日期:2013-09-01 00:00:00
abstract::It is debatable whether differences in mitochondrial function exist across skeletal muscle types and whether mouse skeletal muscle mitochondrial function can serve as a valid model for human skeletal muscle mitochondrial function. The aims of this study were to compare and contrast three different mouse skeletal muscl...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.070037
更新日期:2013-04-01 00:00:00
abstract::The effects of 5 weeks of moderate-intensity endurance training on pulmonary oxygen uptake kinetics (V(O(2)) on-kinetics) were studied in 15 healthy men (mean ± SD: age 22.7 ± 1.8 years, body weight 76.4 ± 8.9 kg and maximal V(O(2)) 46.0 ± 3.7 ml kg(-1) min(-1)). Training caused a significant acceleration (P = 0.003) ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.069443
更新日期:2013-04-01 00:00:00
abstract::Improved understanding of the processes involved in infarct healing is required for identification of novel therapeutic targets to limit infarct expansion and consequent long-term ventricular remodelling after myocardial infarction. Infarct healing can be modelled effectively in murine models of coronary artery ligati...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2012.064741
更新日期:2013-03-01 00:00:00
abstract::Previously, we undertook simultaneous recording of ventilation and pulmonary gas exchange in mice and revealed that dopamine D(2) receptors participate in exercise hyperpnoea via behavioural control of ventilation with unchanged pulmonary gas exchange. Here, we examined the hypothesis that D(1) receptors also contribu...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.068312
更新日期:2013-02-01 00:00:00
abstract::This investigation was designed to determine the participation of the vagus nerve and muscarinic receptors in the remote ischaemic preconditioning (rIPC) mechanism. New Zealand rabbits were anaesthetized, and the femoral artery was dissected. After 30 min of monitoring, the hearts were isolated and subjected to 30 min...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.066217
更新日期:2013-02-01 00:00:00
abstract::Progressive asphyxia, produced by a prolonged voluntary breath hold (end-expiratory apnoea), evokes large bursts of muscle sympathetic nerve activity (MSNA). These bursts increase in amplitude until the asphyxic break point is reached, at which point the bursts are inhibited. We tested the hypothesis that lung inflati...
journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
doi:10.1113/expphysiol.2012.067421
更新日期:2013-02-01 00:00:00
abstract::Ageing is associated with skeletal muscle impairment. Changes in mitochondrial homeostasis are thought to play a key role in this process. This study examined whether chronic intake of polyphenols (PPs), which are known to be modulators of oxidative stress, might prevent the age-related decline of mitochondrial functi...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.067496
更新日期:2013-02-01 00:00:00
abstract::A sustained postexercise vasodilatation, which is histamine receptor mediated, has been observed following single bouts of whole-body exercise, but the mechanisms that regulate activation of histamine receptors following exercise are undefined. Exploration of vasodilatation after small muscle-mass dynamic or resistanc...
journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
doi:10.1113/expphysiol.2012.066605
更新日期:2013-01-01 00:00:00
abstract::Early vascular changes at the molecular level caused by adoption of a sedentary lifestyle are incompletely characterized. Herein, we employed the rodent wheel-lock model to identify mRNAs in the arterial wall that are responsive to the acute transition from higher to lower levels of daily physical activity. Specifical...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.066076
更新日期:2013-01-01 00:00:00
abstract::The role of testosterone (T) in the regulation of cardiovascular function in females is not well understood. Our goal was to examine the effect of T on cardiomyocyte biology by measuring sarcomere shortening/relaxation and intracellular calcium cycling in adult female Sprague-Dawley rats. The rats were divided into th...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.067009
更新日期:2013-01-01 00:00:00
abstract::Cardiovascular arousal is associated with patterned cortical activity changes. Head-down-tilt bed rest (HDBR) dimishes the baroreflex-mediated cardiac control. The present study tested the hypothesis that HDBR deconditioning would modify the forebrain organization for heart rate (HR) control during baroreflex unloadin...
journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
doi:10.1113/expphysiol.2012.065557
更新日期:2012-12-01 00:00:00
abstract::This study investigated whether sensitivity to nociceptive stimuli is altered in obese rats using established models of inflammatory pain, and using real-time PCR, profiled alterations in expression of key adipokine and inflammatory mediator mRNA (adiponectin, tumor necrosis factor-α, interleukin-1β, cyclooxygenase-2,...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.064220
更新日期:2012-11-01 00:00:00
abstract::Noxious somatic stimulation evokes respiratory and autonomic responses. The mechanisms underlying the responses and the manner in which they are co-ordinated are still unclear. The effects of activation of somatic nociceptive fibres on lumbar sympathetic nerve activity at slow (2-10 Hz) and fast frequency bands (100-1...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.066365
更新日期:2012-10-01 00:00:00
abstract::The physiological mechanisms contributing to sex differences following myocardial infarction (MI) are poorly understood. Given the strong relationship between sympathetic nerve activity (SNA) and outcome, we hypothesized there may be a sex difference in SNA responses to MI. In anaesthetized, open-chest male, female an...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.065615
更新日期:2012-09-01 00:00:00
abstract::To better understand the mechanisms underlying the pulmonary O(2) uptake (V(O(2P))) slow component during high-intensity exercise, we used (31)P magnetic resonance spectroscopy, gas exchange, surface electromyography and near-infrared spectroscopy measurements to examine the potential relationship between the slow com...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.062927
更新日期:2012-08-01 00:00:00
abstract::Current assessments of the effects of shear patterns on vascular function assume that a parabolic velocity profile is always present. Any substantial deviation in the profile away from this may result in misinterpretation of the importance that shear patterns have on vascular function. The present investigation tested...
journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
doi:10.1113/expphysiol.2011.064212
更新日期:2012-07-01 00:00:00
abstract::We tested the hypothesis that, among conditions of matched contractile work, shorter contraction durations and greater muscle fibre recruitment result in augmented skeletal muscle blood flow and oxygen consumption ( ) during steady-state exercise in humans. To do so, we measured forearm blood flow (FBF; Doppler ultras...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.062968
更新日期:2012-06-01 00:00:00
abstract::Plasticity of insulin secretion is essential to maintain the action of insulin during insulin resistance and to prevent diabetes. Investigation of the plasticity of insulin secretion and its regulation is challenging, and the objective of this study was to develop a novel large-animal-based model. The effect of chroni...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.063560
更新日期:2012-05-01 00:00:00
abstract::An energy-rich diet leads to enhanced ruminal Na(+) absorption, which is associated with elevated plasma insulin-like growth factor 1 (IGF-1) levels and an increased number of IGF-1 receptors in rumen papillae. This study examined the in vitro effect of IGF-1 on Na(+) transport across the rumen epithelium of hay-fed s...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.061580
更新日期:2012-04-01 00:00:00
abstract::House dust mite (HDM) is a major source of allergen in house dust and has been suggested to be involved in the pathogenesis of asthma. In this study, we aimed to investigate whether HDM can modulate the sensitivity of pulmonary sensory neurons and, if so, to elucidate the underlying mechanism. Fura-2-based ratiometric...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.060764
更新日期:2012-04-01 00:00:00
abstract::Moderate-intensity endurance exercise training improves vascular endothelial vasomotor function; however, the impact of high-intensity exercise training has been equivocal. Thus, the effect of the physiological stress of the exercise remains poorly understood. Furthermore, enhanced vascular repair mediated by circulat...
journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
doi:10.1113/expphysiol.2011.062836
更新日期:2012-03-01 00:00:00
abstract::The spatiotemporal dynamics of intracellular calcium within the middle cerebral artery (MCA) isolated from stroke-prone spontaneously hypertensive rats (SHR-SP) were investigated using real-time confocal laser microscopy. At 3 months of age (prestroke), rhythmical changes in the [Ca(2+)](i) during the tonic phase were...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.061499
更新日期:2012-02-01 00:00:00
abstract::Neural activation decreases cerebral deoxyhaemoglobin (HHb(C)) and increases oxyhaemoglobin concentration (O(2)Hb(C)). In contrast, patients who present with restricted cerebral blood flow, such as those suffering from cerebral ischaemia or Alzheimer's disease, and during the course of ageing the converse occurs, in t...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.061978
更新日期:2012-02-01 00:00:00
abstract::There are abundant animal data attempting to identify the neural circuitry involved in cardiovascular control. Translating this research into humans has been made possible using functional neurosurgery during which deep brain stimulating electrodes are implanted into various brain nuclei for the treatment of chronic p...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2011.060848
更新日期:2012-01-01 00:00:00
abstract::Hypertension caused by chronic infusion of angiotensin II (Ang II) in experimental animals is dependent, in part, on increased activity of the sympathetic nervous system. This chronic sympathoexcitatory response is amplified by a high-salt diet, suggesting an interaction of circulating Ang II and dietary salt on sympa...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.060491
更新日期:2012-01-01 00:00:00
abstract::Power spectral analysis of heart rate variability has often been used to assess cardiac autonomic function; however, the relationship of low-frequency (LF) power of heart rate variability to cardiac sympathetic tone has been unclear. With or without adjustment for high-frequency (HF) power, total power or respiration,...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2010.056259
更新日期:2011-12-01 00:00:00
abstract::Duchenne muscular dystrophy is a devastating muscular dystrophy of childhood. Mutations in the dystrophin gene destroy the link between the internal muscle filaments and the extracellular matrix, resulting in severe muscle weakness and progressive muscle wasting. There is currently no cure and, whilst palliative treat...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2010.053025
更新日期:2011-11-01 00:00:00
abstract::Branched fibres are a well-documented phenomenon of regenerating skeletal muscle. They are found in the muscles of boys with Duchenne muscular dystrophy (DMD), a severe condition of progressive muscle wasting caused by an absence of the sarcolemmal protein dystrophin, and in the muscles of the mdx mouse, an animal mod...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2010.056713
更新日期:2011-06-01 00:00:00
abstract::Hypoglossal nerve activity (HNA) controls the position and movements of the tongue. In persons with compromised upper airway anatomy, sleep-related hypotonia of the tongue and other pharyngeal muscles causes increased upper airway resistance, or total upper airway obstructions, thus disrupting both sleep and breathing...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2010.056242
更新日期:2011-05-01 00:00:00
abstract::Using real-time two-photon laser scanning microscopy, we have demonstrated that lysophosphatidic acid (LPA), a bioactive lipid mediator, causes shear stress-dependent oscillatory local increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fluo-4-loaded endothelial cells of isolated mouse aortic strips in sit...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.056416
更新日期:2011-04-01 00:00:00
abstract::Vagal activity is thought to influence atrial electrophysiological properties and play a role in the initiation and maintenance of atrial fibrillation (AF). We evaluated the effects of acute vagal stimulation on atrial conduction, refractoriness of atrial and pulmonary veins (PVs) and inducibility of AF. An open-chest...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2010.053280
更新日期:2011-02-01 00:00:00
abstract::Beneficial effects of exercise training on the vasculature have been consistently reported in subjects with cardiovascular risk factors or disease, whereas studies in apparently healthy subjects have been less uniform. In this review, we examine evidence pertaining to the impact of exercise training on conduit and res...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2009.048694
更新日期:2011-02-01 00:00:00